Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063700 | 1.00 | BTK (0.41) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL20063768 | 0.84 | CA12 (0.38) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL20063757 | 0.82 | BTK (0.39) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL20063705 | 0.82 | BTK (0.39) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL20073158 | 0.82 | BTK (0.39) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL24062328 | 0.80 | BTK (0.44) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL5315178 | 0.80 | BTK (0.44) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL13813883 | 0.80 | BTK (0.46) | BTKKDM1AMAOBNFKB1NFKB2 | |
| SCHEMBL20063702 | 0.79 | BTK (0.50) | BTKKDM1AMAOBMAOANFKB1 | |
| SCHEMBL23096323 | 0.79 | BTK (0.43) | BTKKDM1AMAOBMAOANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | BTK 645/4885KDM1A 2873/4885MAOB 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.