Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073521 | 0.88 | HPGD (0.53) | L3MBTL1ALDH1A1POLBMAPK14SMN1; SMN2 | |
| SCHEMBL12068769 | 0.88 | PTGS1 (0.49) | PTGS1PTGS2ALDH1A1MAPK14ESRRG | |
| SCHEMBL14454205 | 0.87 | ALDH1A1 (0.59) | L3MBTL1ALDH1A1POLBMAPK14SMN1; SMN2 | |
| SCHEMBL20206539 | 0.83 | CNR2 (0.52) | ALDH1A1MAPK14ESRRGKMT2AHPGD | |
| SCHEMBL13753150 | 0.82 | KMT2A (0.60) | L3MBTL1ALDH1A1POLBMAPK14SMN1; SMN2 | |
| SCHEMBL20978224 | 0.80 | MAPK14 (0.44) | L3MBTL1ALDH1A1POLBMAPK14SMN1; SMN2 | |
| SCHEMBL11631713 | 0.80 | GAA (0.60) | L3MBTL1PTGS1PTGS2ALDH1A1POLB | |
| SCHEMBL20064048 | 0.79 | HDAC6 (0.46) | MAPK14SMN1; SMN2KDM4EGAAHPGD | |
| SCHEMBL20064055 | 0.79 | KMT2A (0.62) | L3MBTL1ALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL18432597 | 0.78 | MAPT (0.56) | L3MBTL1ALDH1A1POLBMAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K5 | L3MBTL1 2788/4885PTGS1 2481/4885PTGS2 2841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.