Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792388 | 0.87 | SLC6A2 (0.48) | KDM4EL3MBTL1MPIALOX5APFEN1 | |
| SCHEMBL21222053 | 0.79 | KDM4E (0.44) | KDM4EL3MBTL1MPIARSLC40A1 | |
| SCHEMBL20064220 | 0.79 | KDM4E (0.44) | KDM4EL3MBTL1MPIARSLC40A1 | |
| SCHEMBL20554735 | 0.78 | MCHR1 (0.48) | KDM4EL3MBTL1PDE4DALOX5APFEN1 | |
| SCHEMBL20944544 | 0.76 | KDM4E (0.49) | KDM4EL3MBTL1PDE4DPDE4APDE4B | |
| SCHEMBL30744993 | 0.76 | KDM4E (0.49) | KDM4EL3MBTL1PDE4DPDE4APDE4B | |
| SCHEMBL20064284 | 0.76 | KDM4E (0.42) | KDM4EL3MBTL1MPIPDE4DPDE4A | |
| SCHEMBL23212187 | 0.76 | KDM4E (0.41) | KDM4EL3MBTL1PDE4DPDE5APDE4A | |
| SCHEMBL31134074 | 0.76 | HSP90AA1 (0.50) | KDM4EPDE4DARMCHR1 | |
| SCHEMBL31134071 | 0.76 | KDM4E (0.41) | KDM4EL3MBTL1PDE4DPDE5APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |