Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.35 |
| ▸ | PDE4A | P27815 | 6/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222484 | 0.85 | PDE4D (0.38) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL21222480 | 0.85 | PDE4D (0.38) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL21227930 | 0.85 | PDE4D (0.38) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL20064509 | 0.83 | NPC1 (0.50) | MEN1NPC1RAB9AKMT2APPARA | |
| SCHEMBL20065559 | 0.79 | NPC1 (0.41) | MEN1NPC1RAB9AKMT2APPARA | |
| SCHEMBL21222653 | 0.77 | HPGDS (0.44) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL21222656 | 0.77 | HPGDS (0.44) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL21221974 | 0.76 | HPGDS (0.44) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20065702 | 0.76 | HPGDS (0.44) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL21221977 | 0.75 | HPGDS (0.45) | MEN1KMT2APDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |