Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 4/20 | 1.00 |
| ▸ | VDR | P11473 | 2/20 | 1.00 |
| ▸ | SLC10A2 | Q12908 | 3/20 | 0.81 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.79 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.79 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Taurolithocholic Acid SCHEMBL22727921 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL13851634 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL18739521 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL18762171 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL17309133 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL24001385 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL364160 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL19360928 | 1.00 | GPBAR1 (1.00) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| Taurolithocholic Acid SCHEMBL29421664 | 0.99 | GPBAR1 (0.98) | GPBAR1ABCC4VDRSLC10A2NR1H4 | |
| SCHEMBL18713247 | 0.95 | GPBAR1 (0.90) | GPBAR1ABCC4VDRSLC10A2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105533-A1 | BILE ACID RECEPTOR MODULATORS AND METHODS OF USE THEREOF | CITY OF HOPE | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105533-A1 | BILE ACID RECEPTOR MODULATORS AND METHODS OF USE THEREOF | NR1H4, GPBAR1, SLC10A2 | GPBAR1 2/4885ABCC4 1785/4885VDR 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.