Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.70 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286563 | 0.84 | MCHR1 (0.51) | MCHR1SNCANPC1RAB9AMAP3K5 | |
| SCHEMBL20067634 | 0.83 | MCHR1 (0.50) | MCHR1SNCANQO2DEGS1MEN1 | |
| SCHEMBL22457376 | 0.83 | MCHR1 (0.73) | MCHR1SNCANPC1RAB9AMAP3K5 | |
| SCHEMBL13920889 | 0.82 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL22288989 | 0.82 | MCHR1 (0.49) | MCHR1SNCANPC1RAB9ANQO2 | |
| SCHEMBL20374775 | 0.82 | MCHR1 (0.72) | MCHR1SNCANPC1RAB9AMAP3K5 | |
| SCHEMBL22239367 | 0.82 | MCHR1 (0.49) | MCHR1SNCANPC1RAB9AMAP3K5 | |
| SCHEMBL22289012 | 0.81 | KDM4E (0.53) | MCHR1NPC1RAB9APOLBKMT2A | |
| SCHEMBL17919519 | 0.81 | EGLN1 (0.48) | MCHR1SNCANPC1RAB9AMAP3K5 | |
| SCHEMBL15223848 | 0.81 | MCHR1 (0.49) | MCHR1SNCAMAP3K5NQO2DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3525826-B1 | NON-LINEAR SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF | BYONDIS BV (NL) | 2020-07-22 | — | — | EP | disclosed |
| WO-2018069375-A1 | NON-LINEAR SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF | SYNTHON BIOPHARMACEUTICALS B.V. (NL) | 2018-04-19 | — | — | WO | disclosed |