Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286563 | 0.90 | MCHR1 (0.51) | MCHR1SNCAEGLN1NQO2MAP3K5 | |
| SCHEMBL22288989 | 0.86 | MCHR1 (0.49) | MCHR1SNCAEGLN1NQO2DEGS1 | |
| SCHEMBL17919519 | 0.85 | EGLN1 (0.48) | MCHR1SNCAEGLN1NQO2MAP3K5 | |
| SCHEMBL18792372 | 0.84 | MCHR1 (0.51) | MCHR1SNCAEGLN1NQO2MAP3K5 | |
| SCHEMBL12392220 | 0.84 | MCHR1 (0.52) | MCHR1SNCAEGLN1MAP3K5 | |
| SCHEMBL15223848 | 0.84 | MCHR1 (0.49) | MCHR1SNCAEGLN1NQO2MAP3K5 | |
| SCHEMBL15223973 | 0.84 | SNCA (0.46) | MCHR1SNCAEGLN1NQO2DEGS1 | |
| SCHEMBL22289012 | 0.82 | KDM4E (0.53) | MCHR1EGLN1ESRRGNPC1RAB9A | |
| SCHEMBL20067652 | 0.82 | MCHR1 (0.70) | MCHR1SNCANQO2MAP3K5DEGS1 | |
| SCHEMBL20067634 | 0.79 | MCHR1 (0.50) | MCHR1SNCANQO2DEGS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3525826-B1 | NON-LINEAR SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF | BYONDIS BV (NL) | 2020-07-22 | — | — | EP | disclosed |