Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 8/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.46 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265281 | 0.77 | CHKA (0.64) | CHKAHDAC1MC4RSUCNR1CYP2D6 | |
| SCHEMBL3687427 | 0.76 | CHKA (0.87) | CHKAHDAC1MC4RTNIKCYP2D6 | |
| SCHEMBL26378533 | 0.76 | CHKA (0.62) | CHKAHDAC1MC4RCYP2D6CYP2C19 | |
| SCHEMBL20067657 | 0.76 | LMNA (0.64) | CHKAHDAC1MC4RTNIKSUCNR1 | |
| SCHEMBL26378167 | 0.74 | CHKA (0.59) | CHKAHDAC1MC4RSUCNR1CYP2D6 | |
| SCHEMBL20067656 | 0.72 | CHKA (0.54) | CHKAHDAC1MC4RTNIKSUCNR1 | |
| SCHEMBL21495134 | 0.72 | MC4R (0.71) | CHKAMC4R | |
| SCHEMBL24092724 | 0.72 | LMNA (0.46) | CHKAHDAC1BTKTNIKSUCNR1 | |
| SCHEMBL24061112 | 0.72 | NMT1 (0.57) | CHKAMC4RLMNA | |
| SCHEMBL17465323 | 0.71 | CHKA (1.00) | CHKAMC4RCYP2D6CYP2C19CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523292-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS MER INHIBITORS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2021-12-15 | — | — | EP | disclosed |
| WO-2018071343-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS MER INHIBITORS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2018-04-19 | — | — | WO | disclosed |