Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067933 | 0.91 | SIRT2 (0.71) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067961 | 0.90 | SIRT2 (0.72) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067947 | 0.83 | SIRT2 (0.69) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067944 | 0.83 | SIRT2 (0.72) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20068003 | 0.82 | SIRT2 (0.71) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067942 | 0.81 | SIRT2 (0.65) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067962 | 0.79 | SIRT2 (0.81) | SIRT2ALDH1A1LMNA | |
| SCHEMBL20067983 | 0.79 | SIRT2 (0.74) | SIRT2ALDH1A1LMNAMAPT | |
| SCHEMBL20067956 | 0.78 | SIRT2 (1.00) | SIRT2ALDH1A1LMNA | |
| SCHEMBL20067952 | 0.78 | SIRT2 (0.83) | SIRT2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |