Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067998 | 0.92 | SIRT2 (0.71) | SIRT2MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL20067961 | 0.87 | SIRT2 (0.72) | SIRT2MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL20067947 | 0.84 | SIRT2 (0.69) | SIRT2MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL20067932 | 0.81 | SIRT2 (0.64) | SIRT2MAPTLMNAALDH1A1 | |
| SCHEMBL20067955 | 0.81 | SIRT2 (0.63) | SIRT2MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL19420176 | 0.79 | MAPT (0.70) | SIRT2MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL20067983 | 0.78 | SIRT2 (0.74) | SIRT2MAPTLMNAALDH1A1 | |
| SCHEMBL20067944 | 0.78 | SIRT2 (0.72) | SIRT2MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL20068003 | 0.77 | SIRT2 (0.71) | SIRT2MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL20067933 | 0.76 | SIRT2 (0.71) | SIRT2MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |