Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.80 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068106 | 0.96 | SIRT2 (0.80) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20067960 | 0.89 | SIRT2 (0.88) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20067956 | 0.89 | SIRT2 (1.00) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20067958 | 0.86 | LMNA (0.80) | SIRT2LMNAALDH1A1MAPTHTT | |
| SCHEMBL20067928 | 0.85 | SIRT2 (0.76) | SIRT2LMNAALDH1A1MAPTHTT | |
| SCHEMBL20067970 | 0.84 | SIRT2 (0.70) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20067962 | 0.83 | SIRT2 (0.81) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20067965 | 0.82 | SIRT2 (0.79) | SIRT2LMNAALDH1A1MAPTHTT | |
| SCHEMBL20067953 | 0.82 | SIRT2 (0.67) | SIRT2LMNARAB9AALDH1A1PKM | |
| SCHEMBL20068003 | 0.82 | SIRT2 (0.71) | SIRT2LMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |