Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20081185 | 0.88 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3C3PIK3CBPIK3R1 | |
| SCHEMBL20067862 | 0.88 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3C3PIK3CBPIK3R1 | |
| SCHEMBL20067824 | 0.85 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3C3PIK3CBPIK3R1 | |
| SCHEMBL20067798 | 0.84 | PIK3CD (0.51) | PIK3CDPIK3CGBMPR1BACVR1BTGFBR1 | |
| SCHEMBL20067869 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3CGBMPR1BACVR1BTGFBR1 | |
| SCHEMBL20081196 | 0.83 | LMNA (0.39) | PIK3CDPIK3CGBMPR1BACVR1BTGFBR1 | |
| SCHEMBL20067819 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CGBMPR1BACVR1BTGFBR1 | |
| SCHEMBL20081419 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CGBMPR1BACVR1BTGFBR1 | |
| SCHEMBL20068044 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3C3PIK3CBPIK3R1 | |
| SCHEMBL20061441 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3C3PIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105527-A1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105527-A1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | WEE2, WEE1, ITK | PIK3CD 14/4885PIK3CG 19/4885BMPR1B 4876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.