Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753617 | 0.89 | TP53 (0.56) | TP53MEN1KMT2AANO1FPR2 | |
| SCHEMBL20147571 | 0.86 | CHRNA1 (0.48) | TP53MEN1KMT2AANO1FPR2 | |
| SCHEMBL20068946 | 0.84 | CYP2C19 (0.61) | TP53KMT2AANO1NAMPTNPC1 | |
| SCHEMBL16565618 | 0.83 | ATM (0.49) | KMT2AP2RX7NPC1RAB9A | |
| SCHEMBL20069661 | 0.82 | HCN1 (0.56) | TP53WDR5MEN1KMT2ANPC1 | |
| SCHEMBL20069766 | 0.82 | PRMT5 (0.45) | KMT2APOLB | |
| SCHEMBL20068952 | 0.81 | DYRK1A (0.45) | DRD2DRD3 | |
| SCHEMBL20069737 | 0.80 | MEN1 (0.54) | WDR5MEN1KMT2A | |
| SCHEMBL20147991 | 0.79 | RET (0.46) | TP53KMT2ANPC1RAB9A | |
| SCHEMBL20069767 | 0.79 | RET (0.45) | TP53KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |