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Sugi Predict / Targets / HCN1

HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 · O60741 · HCN1 on Sugi Atlas →

1,644 patent compounds predicted against HCN1, 718 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL13706768 SCHEMBL13706768 0.55 13/20
SCHEMBL13706796 SCHEMBL13706796 0.55 13/20
SCHEMBL4364182 SCHEMBL4364182 0.55 12/20
SCHEMBL4350496 SCHEMBL4350496 0.54 12/20
SCHEMBL13706973 SCHEMBL13706973 0.52 12/20
SCHEMBL4356002 SCHEMBL4356002 0.51 12/20
SCHEMBL4835318 SCHEMBL4835318 0.51 12/20
SCHEMBL5248647 SCHEMBL5248647 0.49 12/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL4834372) 0.48 12/20
SCHEMBL4535037 SCHEMBL4535037 0.55 11/20
SCHEMBL13706774 SCHEMBL13706774 0.55 11/20
SCHEMBL4353725 SCHEMBL4353725 0.54 11/20
SCHEMBL13706772 SCHEMBL13706772 0.54 11/20
SCHEMBL13706860 SCHEMBL13706860 0.54 11/20
SCHEMBL4351955 SCHEMBL4351955 0.54 11/20
SCHEMBL16510802 SCHEMBL16510802 0.54 11/20
SCHEMBL4374231 SCHEMBL4374231 0.52 11/20
SCHEMBL13706783 SCHEMBL13706783 0.51 11/20
SCHEMBL13706785 SCHEMBL13706785 0.50 11/20
SCHEMBL4374590 SCHEMBL4374590 0.57 10/20

Clinical trials — most relevant to HCN1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK) PHASE2/PHASE3RECRUITING
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy PHASE3COMPLETED
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial PHASE2WITHDRAWN
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN) PHASE1/PHASE2RECRUITING
Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN PHASE2RECRUITING
StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2 PHASE2RECRUITING
An Open-Label Study to Investigate the Safety of Single and Multiple Ascending Doses in Children and Adolescents With Dravet Syndrome PHASE1/PHASE2COMPLETED
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (Australia Only) PHASE1/PHASE2ACTIVE_NOT_RECRUITING
High Definition Cathodal Transcranial Direct Current Stimulation for Treatment of Refractory Partial Onset Epilepsy PHASE1COMPLETED
HNC: Human Neural Circuits Electrophysiology During Cognition PHASE1RECRUITING
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome nanCOMPLETED
MS Fatigue and tDCS on Fatigue in Multiple Sclerosis nanCOMPLETED
Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings nanCOMPLETED
Measuring Single Neuron Activity in the Brain nanNOT_YET_RECRUITING
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia nanCOMPLETED
The Energetic Origin of Neurodegeneration in MS nanCOMPLETED
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods nanCOMPLETED
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases nanUNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Non-invasive Brain Stimulation for Pediatric ADHD nanCOMPLETED
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC. nanNOT_YET_RECRUITING
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development nanRECRUITING
Effect of Stimulation of Dorsolateral Prefrontal Cortex on Language Control nanCOMPLETED
Role of SNP and DIGOXIN Response in Atrial Fibrillation Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HCN1 binder may also engage these)

ProteinNameSimilarity
Q9JKB0 — 1.000 Q9JKB0 →
Q9MZS1 — 1.000 Q9MZS1 →
O88704 — 1.000 O88704 →
Q60603 — 0.996 Q60603 →
Q02280 — 0.993 Q02280 →
Q9JKA7 — 0.993 Q9JKA7 →
HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 0.991 landscape →
KCNH1 Voltage-gated delayed rectifier potassium channel KCNH1 0.991 landscape →
Q8NCM2 — 0.991 Q8NCM2 →
Q9Z0V1 — 0.991 Q9Z0V1 →
Q920E3 — 0.990 Q920E3 →
Q63472 — 0.990 Q63472 →
Q62897 — 0.990 Q62897 →
Q9EPI9 — 0.989 Q9EPI9 →
Q9JKA9 — 0.989 Q9JKA9 →
Q90805 — 0.989 Q90805 →
O70507 — 0.989 O70507 →
Q9TTT5 — 0.988 Q9TTT5 →
Q16281 — 0.987 Q16281 →
A6H8H5 — 0.987 A6H8H5 →
O88703 — 0.987 O88703 →
Q63099 — 0.987 Q63099 →
Q9TUI4 — 0.987 Q9TUI4 →
KCNB1 Potassium voltage-gated channel subfamily B member 1 0.987 landscape →
P15387 — 0.986 P15387 →
Q8MJD7 — 0.986 Q8MJD7 →
Q9TV66 — 0.986 Q9TV66 →
O18965 — 0.986 O18965 →
P17970 — 0.986 P17970 →
Q4ZHA6 — 0.986 Q4ZHA6 →