Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.57 |
| ▸ | BACE1 | P56817 | 12/20 | 0.57 |
| ▸ | BCHE | P06276 | 11/20 | 0.57 |
| ▸ | FABP6 | P51161 | 1/20 | 0.57 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11727639 | 0.90 | ACHE (0.65) | ACHEBACE1BCHEFABP6CARM1 | |
| SCHEMBL9965855 | 0.83 | ACHE (0.54) | ACHEBACE1BCHEFABP6CARM1 | |
| SCHEMBL20158440 | 0.82 | BCHE (0.62) | ACHEBACE1BCHEFABP6CARM1 | |
| SCHEMBL20069021 | 0.81 | ACHE (0.54) | ACHEBACE1BCHEFABP6CARM1 | |
| SCHEMBL8081164 | 0.80 | ACHE (0.68) | ACHEBACE1BCHEFABP6CARM1 | |
| SCHEMBL28511753 | 0.80 | BCHE (0.83) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL28496734 | 0.80 | BCHE (0.83) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL2241661 | 0.78 | ACHE (0.54) | ACHEBACE1BCHEFABP6KMT2A | |
| SCHEMBL994595 | 0.78 | ACHE (0.54) | ACHEBACE1BCHEFABP6KMT2A | |
| SCHEMBL2954218 | 0.77 | GRIN2B (0.69) | ACHEBACE1BCHEFABP6CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20200383966-A9 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-12-10 | — | — | US | disclosed |
| US-20200030311-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2020-01-30 | — | — | US | disclosed |
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |
| CN-107021916-A | A kind of preparation method of trans -3- methyl -5- benzylamino piperidines | 浙江医药股份有限公司 | 2017-08-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200383966-A9 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | ACHE 4091/4885BACE1 3478/4885BCHE 4084/4885 |
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | ACHE 4091/4885BACE1 3478/4885BCHE 4084/4885 |
| US-20200030311-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | ACHE 4091/4885BACE1 3478/4885BCHE 4084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.