Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147320 | 0.87 | SETD7 (0.36) | SETD7GPR119MAP4K4NR1H2RET | |
| SCHEMBL20069057 | 0.79 | USP2 (0.43) | NR1H2CHRM4 | |
| SCHEMBL20070277 | 0.79 | RET (0.51) | SETD7GPR119MAP4K4RET | |
| SCHEMBL20069528 | 0.79 | RET (0.52) | SETD7GPR119MAP4K4NR1H2RET | |
| SCHEMBL1920854 | 0.78 | SETD7 (0.42) | SETD7GPR119MAP4K4NR1H2HDAC1 | |
| SCHEMBL15312664 | 0.78 | SETD7 (0.42) | SETD7GPR119MAP4K4NR1H2HDAC1 | |
| SCHEMBL29914717 | 0.78 | SETD7 (0.42) | SETD7GPR119MAP4K4NR1H2HDAC1 | |
| SCHEMBL25501956 | 0.78 | PSEN1 (0.39) | SETD7GPR119MAP4K4NR1H2DRD2 | |
| SCHEMBL19504105 | 0.77 | SETD7 (0.41) | SETD7GPR119MAP4K4NR1H2HDAC1 | |
| SCHEMBL13895338 | 0.77 | SETD7 (0.41) | SETD7GPR119MAP4K4NR1H2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |