Sugi Predict

Sugi Predict / Compounds / SCHEMBL20069155

SCHEMBL20069155

SCHEMBL20069155

CC(C)COC(=O)NC1(C)CCN(C)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 3/20 0.38
▸ GHSR Q92847 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ DRD2 P14416 1/20 0.34
▸ TSHR P16473 5/20 0.34
▸ FSHR P23945 2/20 0.34
▸ RAB9A P51151 1/20 0.33
▸ HSD11B1 P28845 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ NFKB1 P19838 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20147469 0.86 RET (0.38) RETGHSRSMN1; SMN2TSHRFSHR
SCHEMBL20206056 0.84 RET (0.37) RETGHSRSMN1; SMN2TSHRFSHR
SCHEMBL25503101 0.82 RET (0.36) RETGHSRSMN1; SMN2TSHRFSHR
SCHEMBL20069513 0.82 OPRM1 (0.43) RETALDH1A1HSD17B10LMNASLC22A1
SCHEMBL20069713 0.80 RET (0.42) RETGHSRSMN1; SMN2DRD2TSHR
SCHEMBL24763400 0.79 OPRM1 (0.37) TSHRRAB9AALDH1A1MEN1LMNA
SCHEMBL20069704 0.79 RET (0.37) RETDRD2TSHRRAB9AKDM4E
SCHEMBL22857038 0.77 HDAC1 (0.42) RETHDAC1HDAC2
SCHEMBL20069043 0.76 SMN1; SMN2 (0.42) RETSMN1; SMN2ALDH1A1LMNACYP2C9
SCHEMBL20069702 0.76 RET (0.35) RETGHSRSMN1; SMN2DRD2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2020-12-10 — — US disclosed
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2020-01-30 — — US disclosed
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-08 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
WO-2018071454-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ANDREWS STEVEN W (US) 2018-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885GHSR 1829/4885SMN1; SMN2 646/4885
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885GHSR 1829/4885SMN1; SMN2 646/4885
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 RET 1/4885GHSR 1829/4885SMN1; SMN2 646/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885GHSR 1829/4885SMN1; SMN2 646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.