Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 16/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147590 | 0.89 | RET (0.50) | RETP2RX7HDAC4 | |
| SCHEMBL20068930 | 0.87 | RET (0.52) | RETP2RX7HDAC4 | |
| SCHEMBL20069673 | 0.86 | RET (0.52) | RETOPRM1 | |
| SCHEMBL20069663 | 0.85 | RET (0.52) | RET | |
| SCHEMBL20068938 | 0.84 | RET (0.55) | RET | |
| SCHEMBL20069662 | 0.81 | RET (0.50) | RETP2RX7OPRM1 | |
| SCHEMBL20068931 | 0.80 | RET (0.47) | RET | |
| SCHEMBL20158879 | 0.78 | RET (0.54) | RETP2RX7HDAC4 | |
| SCHEMBL20069741 | 0.78 | RET (0.46) | RET | |
| SCHEMBL20147597 | 0.77 | RET (0.51) | RETP2RX7HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |