Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 17/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068931 | 0.92 | RET (0.47) | RETCCR3 | |
| SCHEMBL20069744 | 0.90 | RET (0.45) | RET | |
| SCHEMBL20147554 | 0.85 | RET (0.45) | RETUSP30CCR3 | |
| SCHEMBL20152062 | 0.84 | RET (0.42) | RETUSP30CCR3 | |
| SCHEMBL20069762 | 0.82 | CCR3 (0.44) | RETUSP30CCR3SLC6A9 | |
| SCHEMBL20147539 | 0.81 | RET (0.46) | RETCCR3 | |
| SCHEMBL21651991 | 0.81 | CCR3 (0.49) | RETCCR3 | |
| SCHEMBL20068927 | 0.81 | CCR3 (0.45) | RETUSP30CCR3 | |
| SCHEMBL20069734 | 0.79 | RET (0.50) | RETCCR3 | |
| SCHEMBL20147546 | 0.79 | RET (0.40) | RETCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |