Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147506 | 0.86 | EPHX1 (0.47) | EPHX1RETGHSRKDM4EEPHX2 | |
| SCHEMBL20069520 | 0.85 | RET (0.43) | EPHX1RETKDM4EEPHX2SMN1; SMN2 | |
| SCHEMBL25503136 | 0.81 | EPHX1 (0.33) | EPHX1RETKDM4EHSD11B1SIGMAR1 | |
| SCHEMBL20069716 | 0.81 | RET (0.43) | EPHX1RETKDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL20069701 | 0.81 | RET (0.37) | EPHX1RETEPHX2 | |
| SCHEMBL20069705 | 0.79 | RET (0.41) | EPHX1RETKDM4EEPHX2 | |
| SCHEMBL20069719 | 0.78 | RET (0.41) | EPHX1RETKDM4EKEAP1NFE2L2 | |
| SCHEMBL20069696 | 0.78 | RET (0.41) | EPHX1RETKDM4EEPHX2HSD11B1 | |
| SCHEMBL20069697 | 0.77 | RET (0.43) | RET | |
| SCHEMBL20069726 | 0.76 | RET (0.42) | EPHX1RETKDM4ESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |