Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069712 | 0.89 | RET (0.41) | RETTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20147508 | 0.88 | RET (0.42) | RETTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20069522 | 0.85 | RET (0.43) | RETTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL20069696 | 0.83 | RET (0.41) | RETTP53KDM4EEPHX1SIGMAR1 | |
| SCHEMBL20068982 | 0.82 | KDM4E (0.44) | RETTP53SMN1; SMN2KDM4EEPHX1 | |
| SCHEMBL25503136 | 0.81 | EPHX1 (0.33) | RETKDM4EEPHX1SIGMAR1 | |
| SCHEMBL20069726 | 0.81 | RET (0.42) | RETKDM4EEPHX1SIGMAR1 | |
| SCHEMBL20068983 | 0.81 | RET (0.42) | RETALDH1A1KDM4EEPHX1SIGMAR1 | |
| SCHEMBL20069706 | 0.81 | EPHX1 (0.50) | RETSMN1; SMN2KDM4EEPHX1SIGMAR1 | |
| SCHEMBL20069702 | 0.81 | RET (0.35) | RETSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |