Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18705150 | 0.83 | CYP2D6 (0.39) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL9963293 | 0.78 | CYP2D6 (0.36) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL24576856 | 0.76 | CYP2D6 (0.35) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL12403199 | 0.76 | CHEK1 (0.36) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL12257643 | 0.75 | CHRNB2 (0.33) | CYP2D6 | |
| SCHEMBL12890329 | 0.73 | CYP2D6 (0.39) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL21210820 | 0.73 | CYP2D6 (0.30) | CYP2D6 | |
| SCHEMBL10111445 | 0.73 | CYP2D6 (0.46) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL20926925 | 0.72 | CYP2D6 (0.33) | CYP2D6 | |
| SCHEMBL20007912 | 0.72 | CYP2D6 (0.36) | CYP2D6KDM4EMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |