Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147513 | 0.86 | RET (0.42) | RETCHRM3BCHE | |
| SCHEMBL20069719 | 0.81 | RET (0.41) | RET | |
| SCHEMBL20069701 | 0.81 | RET (0.37) | RETHDAC1HDAC2HDAC3CHRM3 | |
| SCHEMBL22857038 | 0.80 | HDAC1 (0.42) | RETHDAC1HDAC2HDAC3CHRM3 | |
| SCHEMBL20069713 | 0.80 | RET (0.42) | RET | |
| SCHEMBL20069723 | 0.80 | RET (0.42) | RET | |
| SCHEMBL20158431 | 0.71 | RET (0.39) | RET | |
| SCHEMBL20069525 | 0.70 | RET (0.41) | RET | |
| SCHEMBL20069711 | 0.70 | RET (0.40) | RET | |
| SCHEMBL20148067 | 0.70 | RET (0.40) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |