Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | FSHR | P23945 | 5/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21651959 | 0.86 | RET (0.43) | RETDPP8DPP9KMT2ATSHR | |
| SCHEMBL20147517 | 0.85 | RET (0.41) | RETDPP8DPP9KMT2ATSHR | |
| SCHEMBL20206052 | 0.84 | RET (0.40) | RETKMT2ATSHRFSHR | |
| SCHEMBL20069713 | 0.81 | RET (0.42) | RETTSHRFSHRALDH1A1 | |
| SCHEMBL20069722 | 0.80 | RET (0.43) | RET | |
| SCHEMBL20158431 | 0.72 | RET (0.39) | RETKMT2AALDH1A1 | |
| SCHEMBL20069525 | 0.71 | RET (0.41) | RETALDH1A1 | |
| SCHEMBL20069711 | 0.71 | RET (0.40) | RET | |
| SCHEMBL20148067 | 0.71 | RET (0.40) | RETKMT2AMEN1ALDH1A1 | |
| SCHEMBL20068870 | 0.71 | RET (0.40) | RETKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |