Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BCL3 | P20749 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068928 | 0.92 | MAPK1 (0.43) | ALDH1A1KDM4EGAATHRBRET | |
| SCHEMBL20069768 | 0.84 | RET (0.42) | ALDH1A1KDM4EGAATHRBRET | |
| SCHEMBL20147545 | 0.83 | RET (0.41) | KDM4EGAATHRBUSP30RET | |
| SCHEMBL20152064 | 0.83 | P2RX7 (0.39) | RETSLC6A9 | |
| SCHEMBL20069735 | 0.83 | RET (0.49) | ALDH1A1GAARETMAPT | |
| SCHEMBL20147568 | 0.80 | P2RX7 (0.40) | RETLMNACYP2D6 | |
| SCHEMBL20206040 | 0.80 | DPP4 (0.43) | ALDH1A1RETMEN1KMT2ASLC6A9 | |
| SCHEMBL20069339 | 0.79 | RET (0.41) | USP30RETMAPK1MEN1KMT2A | |
| SCHEMBL22660413 | 0.78 | CYP2C19 (0.46) | ALDH1A1RETMAPK1MEN1KMT2A | |
| SCHEMBL20068944 | 0.77 | HPGD (0.44) | USP30RETMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |