Sugi Predict

Sugi Predict / Compounds / SCHEMBL20069848

SCHEMBL20069848

SCHEMBL20069848

CC(C)N1CC2CC(C1)N2S(=O)(=O)Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.42
▸ TSHR P16473 3/20 0.42
▸ HPGD P15428 2/20 0.42
▸ KDM4E B2RXH2 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ KMT2A Q03164 3/20 0.39
▸ ALDH1A1 P00352 5/20 0.39
▸ MAPT P10636 3/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ MEN1 O00255 2/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ PKM P14618 1/20 0.37
▸ HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19014525 0.91 POLB (0.48) POLBTSHRHPGDKDM4EMCL1
SCHEMBL20153171 0.84 TSHR (0.45) POLBTSHRHPGDKMT2AALDH1A1
SCHEMBL20149637 0.80 POLB (0.42) POLBTSHRHPGDKMT2AALDH1A1
SCHEMBL20682266 0.78 JAK2 (0.35) POLBTSHRKMT2ANPSR1MEN1
SCHEMBL20682272 0.77 JAK2 (0.39) ALDH1A1MAPTHSD17B10HTT
SCHEMBL19798474 0.75 CHRM2 (0.50) POLBTSHRHPGDKMT2AALDH1A1
SCHEMBL20682350 0.75 KIF11 (0.40) HTT
SCHEMBL19013698 0.75 POLB (0.51) POLBTSHRHPGDKMT2AALDH1A1
SCHEMBL18705127 0.74 CHRM2 (0.53) KDM4EKMT2AALDH1A1MAPTNPSR1
SCHEMBL2218867 0.73 HPGD (0.54) POLBTSHRHPGDKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2021-06-24 — — US disclosed
EP-3753939-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS Array Biopharma Inc. (US) 2020-12-23 — — EP disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
WO-2018071447-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ANDREWS STEVEN W (US) 2018-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF POLB 3678/4885TSHR 1461/4885HPGD 3857/4885
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF POLB 3678/4885TSHR 1461/4885HPGD 3857/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF POLB 3678/4885TSHR 1461/4885HPGD 3857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.