Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147371 | 0.84 | SIGMAR1 (0.47) | SIGMAR1HRH3ALDH1A1NPC1KMT2A | |
| SCHEMBL20147953 | 0.73 | RET (0.49) | HRH3ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL20147357 | 0.70 | KDM4E (0.48) | SIGMAR1HRH3ALDH1A1KMT2AMEN1 | |
| SCHEMBL20070114 | 0.70 | SMN1; SMN2 (0.49) | ALDH1A1POLBSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL13417680 | 0.69 | CHRM5 (0.70) | SIGMAR1ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL25094566 | 0.69 | SIGMAR1 (0.51) | SIGMAR1HRH3ALDH1A1NPC1POLB | |
| SCHEMBL10289279 | 0.68 | SIGMAR1 (0.68) | SIGMAR1HRH3ALDH1A1NPC1KMT2A | |
| SCHEMBL20147518 | 0.68 | RET (0.40) | SIGMAR1HRH3POLBCYP3A4GAA | |
| SCHEMBL18704948 | 0.67 | GAA (0.71) | SIGMAR1HRH3ALDH1A1GAA | |
| SCHEMBL7721235 | 0.67 | CHRM5 (0.72) | SIGMAR1ALDH1A1NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |