Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205833 | 0.94 | RET (0.39) | RETOPRK1DPP7DRD2SSTR4 | |
| SCHEMBL20147500 | 0.93 | RET (0.38) | RETOPRK1DPP7DRD2SSTR4 | |
| SCHEMBL21651988 | 0.91 | RET (0.37) | RETOPRK1DPP7DRD2SSTR4 | |
| SCHEMBL22857066 | 0.90 | RET (0.37) | RETOPRK1DPP7DRD2SSTR4 | |
| SCHEMBL20626703 | 0.90 | RET (0.40) | RETOPRK1DPP7DRD2SSTR4 | |
| SCHEMBL21651960 | 0.75 | RET (0.41) | RETDRD2TP53 | |
| SCHEMBL20158493 | 0.73 | RET (0.44) | RETDRD2MEN1KMT2A | |
| SCHEMBL12282454 | 0.73 | HSD11B1 (0.50) | DRD2SSTR4HSD11B1HTR2AFPR2 | |
| SCHEMBL20070138 | 0.72 | RET (0.44) | RETDRD2MEN1KMT2A | |
| SCHEMBL20069523 | 0.72 | RET (0.44) | RETMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |