Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20970608 | 0.94 | L3MBTL1 (0.83) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL7955601 | 0.91 | L3MBTL1 (0.89) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL31677824 | 0.89 | L3MBTL1 (0.86) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL22972207 | 0.89 | L3MBTL1 (0.86) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL18228118 | 0.86 | L3MBTL1 (0.86) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL3390298 | 0.86 | L3MBTL1 (0.86) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL7943306 | 0.86 | L3MBTL1 (1.00) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL21650906 | 0.85 | L3MBTL1 (0.73) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL2677200 | 0.85 | L3MBTL1 (0.78) | L3MBTL1EPHX2GAASMN1; SMN2HTT | |
| SCHEMBL31305639 | 0.84 | L3MBTL1 (0.83) | L3MBTL1EPHX2GAASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |