Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149604 | 0.84 | RET (0.35) | RET | |
| SCHEMBL20148651 | 0.83 | RET (0.38) | RET | |
| SCHEMBL20154553 | 0.82 | RET (0.34) | RET | |
| SCHEMBL20070423 | 0.69 | RET (0.38) | RETGRIN1GRIN2B | |
| SCHEMBL20071341 | 0.67 | RET (0.39) | RET | |
| SCHEMBL22811895 | 0.67 | RET (0.37) | RETGRIN1GRIN2B | |
| SCHEMBL22030584 | 0.67 | TAS2R8 (0.38) | RET | |
| SCHEMBL22031271 | 0.67 | RET (0.37) | RETGRIN1GRIN2B | |
| SCHEMBL20070541 | 0.67 | MAPT (0.42) | RETGRIN1GRIN2B | |
| SCHEMBL22030579 | 0.66 | RET (0.40) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |