TAS2R8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1278315	1.00	20/20
SCHEMBL1278396	1.00	20/20
SCHEMBL1278560	1.00	20/20
SCHEMBL1278561	1.00	20/20
SCHEMBL1278566	1.00	20/20
SCHEMBL1278567	1.00	20/20
SCHEMBL1278611	1.00	20/20
SCHEMBL1278654	1.00	20/20
SCHEMBL1278680	1.00	20/20
SCHEMBL1278682	1.00	20/20
SCHEMBL1278689	1.00	20/20
SCHEMBL1278701	1.00	20/20
SCHEMBL1278707	1.00	20/20
SCHEMBL1278714	1.00	20/20
SCHEMBL1278715	1.00	20/20
SCHEMBL1278732	1.00	20/20
SCHEMBL1278749	1.00	20/20
SCHEMBL1278762	1.00	20/20
SCHEMBL1278797	1.00	20/20
SCHEMBL1278840	1.00	20/20

Clinical trials — most relevant to TAS2R8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Astringency and Oral Health	nan	COMPLETED
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38	nan	COMPLETED
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
Study of Taste Deficits	nan	COMPLETED
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Genetic Variability in Taste Perception	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Alteration of Taste Among Orthodontic Patients Following Clear Aligners Treatment	nan	UNKNOWN
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TAS2R8 binder may also engage these)

Protein	Name	Similarity
Q646A3	—	1.000	Q646A3 →
Q646C5	—	1.000	Q646C5 →
Q646G4	—	1.000	Q646G4 →
Q646E5	—	1.000	Q646E5 →
Q645U8	—	1.000	Q645U8 →
Q7M722	—	1.000	Q7M722 →
TAS2R9	Taste receptor type 2 member 9	1.000	landscape →
Q646G5	—	1.000	Q646G5 →
Q646C6	—	1.000	Q646C6 →
Q7M709	—	1.000	Q7M709 →
Q9JKT5	—	1.000	Q9JKT5 →
Q9JKT8	—	0.999	Q9JKT8 →
TAS2R3	Taste receptor type 2 member 3	0.998	landscape →
Q67ES6	—	0.998	Q67ES6 →
Q645U9	—	0.998	Q645U9 →
Q645V9	—	0.997	Q645V9 →
Q645Z3	—	0.997	Q645Z3 →
Q645T0	—	0.997	Q645T0 →
Q7M725	—	0.996	Q7M725 →
Q645T9	—	0.996	Q645T9 →
Q7M723	—	0.996	Q7M723 →
Q646E8	—	0.996	Q646E8 →
Q9JKT9	—	0.996	Q9JKT9 →
Q645U2	—	0.995	Q645U2 →
P59528	—	0.995	P59528 →
Q646B8	—	0.995	Q646B8 →
Q7TQA8	—	0.995	Q7TQA8 →
P59530	—	0.994	P59530 →
Q67ET3	—	0.994	Q67ET3 →
Q67ES9	—	0.994	Q67ES9 →