Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154576 | 0.85 | RET (0.42) | RETPDE2AMDM2HTR1ADRD4 | |
| SCHEMBL21158901 | 0.82 | RET (0.39) | RETPDE2AMDM2TRPA1TRPC6 | |
| SCHEMBL20069645 | 0.82 | RET (0.42) | RETGRM2TRPC6HTR2A | |
| SCHEMBL20149632 | 0.82 | RET (0.40) | RETPDE2AMDM2TRPA1CCNC | |
| SCHEMBL20148649 | 0.82 | RET (0.40) | RETPDE2AMDM2TRPA1 | |
| SCHEMBL24135071 | 0.75 | JAK2 (0.37) | RETPDE2AMDM2GRM2GRM3 | |
| SCHEMBL22812225 | 0.72 | ALDH1A1 (0.40) | RETPDE2ADRD4DRD3 | |
| SCHEMBL22812017 | 0.68 | RET (0.44) | RETMDM2TRPC6HTR2A | |
| SCHEMBL20154572 | 0.66 | RET (0.47) | RET | |
| SCHEMBL21158902 | 0.66 | MAPT (0.41) | RETGRM2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |