Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 8/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | NNMT | P40261 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153163 | 0.89 | GPR183 (0.53) | GPR183RETNNMTKCNH2GABRA5 | |
| SCHEMBL21159105 | 0.88 | GPR183 (0.52) | GPR183RETNNMTKCNH2GABRA5 | |
| SCHEMBL23555335 | 0.87 | GPR183 (0.52) | GPR183RETNNMTKCNH2GABRA5 | |
| SCHEMBL20160530 | 0.86 | GPR183 (0.51) | GPR183RETNNMTKCNH2GABRA5 | |
| SCHEMBL20148743 | 0.86 | GPR183 (0.51) | GPR183RETNNMTKCNH2GABRA5 | |
| SCHEMBL30374831 | 0.77 | GPR183 (0.82) | GPR183KCNH2 | |
| SCHEMBL22773723 | 0.72 | GPR183 (0.62) | GPR183NNMTKCNH2PDE2AHPGD | |
| SCHEMBL20070949 | 0.71 | RET (0.46) | RETKCNH2 | |
| SCHEMBL26487961 | 0.69 | GPR183 (1.00) | GPR183KCNH2 | |
| SCHEMBL30014437 | 0.69 | HPGD (0.67) | GPR183HPGDNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |