Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153188 | 0.89 | RET (0.47) | RETFAAHNAAAKCNH2NPC1 | |
| SCHEMBL21159017 | 0.88 | RET (0.46) | RETFAAHNAAAKCNH2NPC1 | |
| SCHEMBL23555337 | 0.87 | RET (0.46) | RETFAAHNAAAKCNH2NPC1 | |
| SCHEMBL20148756 | 0.86 | RET (0.45) | RETFAAHNAAAKCNH2NPC1 | |
| SCHEMBL22031245 | 0.86 | RET (0.49) | RETFAAHNAAAKCNH2KDM4E | |
| SCHEMBL20071375 | 0.76 | KMT2A (0.49) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL21925711 | 0.72 | POLB (0.59) | HTTKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL20070913 | 0.71 | GPR183 (0.52) | RETKCNH2 | |
| SCHEMBL20153278 | 0.69 | NPC1 (0.54) | FAAHNAAANPC1HTTSMN1; SMN2 | |
| SCHEMBL4551548 | 0.69 | KMT2A (0.51) | KCNH2NPC1HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |