SCHEMBL20071283 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	DPP4	P27487	5/20	0.48

▸	DPP8	Q6V1X1	2/20	0.40

▸	DPP9	Q86TI2	2/20	0.40

▸	DPP7	Q9UHL4	2/20	0.40

▸	SLC7A5	Q01650	1/20	0.39

▸	ARG1	P05089	1/20	0.35

▸	RET	P07949	1/20	0.35

▸	ANPEP	P15144	2/20	0.34

▸	RNPEP	Q9H4A4	2/20	0.34

▸	DNPEP	Q9ULA0	1/20	0.34

▸	PEPD	P12955	2/20	0.33

▸	XPNPEP1	Q9NQW7	1/20	0.33

▸	SLC1A3	P43003	2/20	0.32

▸	SLC1A2	P43004	2/20	0.32

▸	SMN1; SMN2	Q16637	1/20	0.31

▸	SLC1A1	P43005	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22031267	0.86	DPP4 (0.49)	DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL20148598	0.84	DPP4 (0.48)	DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL20153214	0.82	DPP4 (0.46)	DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL22031234	0.73	SMN1; SMN2 (0.46)	RETSMN1; SMN2
SCHEMBL17152400	0.69	DPP4 (0.44)	DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL17152345	0.69	DPP4 (0.44)	DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL20069618	0.68	DPP4 (0.33)	DPP4PEPDSLC1A3SLC1A2
SCHEMBL20148597	0.67	DPP4 (0.32)	DPP4SLC1A3SLC1A2
SCHEMBL22031268	0.65	RET (0.37)	DPP4RET
SCHEMBL17152271	0.65	DPP4 (0.44)	DPP4DPP8DPP9DPP7SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018071447-A1	SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS	ANDREWS STEVEN W (US)	2018-04-19	—	—	WO	disclosed