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SCHEMBL20148598

SCHEMBL20148598

CC(C)CC(N)C(=O)N1C2CC1CN(C(C)C)C2

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 9/20 0.48
▸ DPP8 Q6V1X1 4/20 0.40
▸ DPP9 Q86TI2 4/20 0.40
▸ DPP7 Q9UHL4 3/20 0.40
▸ SLC7A5 Q01650 1/20 0.39
▸ ARG1 P05089 1/20 0.35
▸ RET P07949 1/20 0.35
▸ ANPEP P15144 2/20 0.34
▸ RNPEP Q9H4A4 2/20 0.34
▸ DNPEP Q9ULA0 1/20 0.34
▸ PEPD P12955 2/20 0.33
▸ XPNPEP1 Q9NQW7 1/20 0.33
▸ SLC1A3 P43003 2/20 0.32
▸ SLC1A2 P43004 2/20 0.32
▸ FAP Q12884 1/20 0.31
▸ SLC1A1 P43005 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20153214 0.88 DPP4 (0.46) DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL22031267 0.86 DPP4 (0.49) DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL20071283 0.84 DPP4 (0.48) DPP4DPP8DPP9DPP7SLC7A5
SCHEMBL20148597 0.82 DPP4 (0.32) DPP4SLC1A3SLC1A2
SCHEMBL20071278 0.79 RET (0.36) RET
SCHEMBL20148599 0.78 CHRNB2 (0.41) —
SCHEMBL20148600 0.77 — —
SCHEMBL20148596 0.73 SMN1; SMN2 (0.46) RET
SCHEMBL20148602 0.73 RAB9A (0.40) RET
SCHEMBL17856434 0.72 SMN1; SMN2 (0.37) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-10953005-B1 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-03-23 — — US disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF DPP4 1948/4885DPP8 2296/4885DPP9 2038/4885
US-10953005-B1 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors RET, ROR1, BRAF DPP4 1948/4885DPP8 2296/4885DPP9 2038/4885
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF DPP4 1948/4885DPP8 2296/4885DPP9 2038/4885
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF DPP4 1948/4885DPP8 2296/4885DPP9 2038/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF DPP4 1948/4885DPP8 2296/4885DPP9 2038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.