Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20071864 | 0.88 | PTPN11 (0.41) | PTGER4CNR2CNR1HSD11B1PIK3C3 | |
| SCHEMBL20071865 | 0.84 | PTGER4 (0.32) | PTGER4CNR1HSD11B1TPH1SMO | |
| SCHEMBL21644403 | 0.83 | PTGER4 (0.32) | PTGER4HSD11B1TPH1MAPK1PTPN11 | |
| SCHEMBL20072210 | 0.82 | ALDH1A1 (0.39) | HSD11B1ALDH1A1SMONR1H2NR1H3 | |
| SCHEMBL20072195 | 0.82 | PTGER4 (0.44) | PTGER4CNR1HSD11B1SMOPTPN11 | |
| SCHEMBL23838140 | 0.82 | NR1H2 (0.42) | PTGER4CNR1PARP1SMONR1H2 | |
| SCHEMBL21644381 | 0.81 | PTGER4 (0.33) | PTGER4PTPN11 | |
| SCHEMBL23838054 | 0.81 | DYRK1A (0.33) | PTGER4KIF18APARP1TPH1SMO | |
| SCHEMBL23838145 | 0.80 | NR1H2 (0.41) | PTGER4CNR2CNR1HSD11B1ALDH1A1 | |
| SCHEMBL23838112 | 0.80 | PTGER4 (0.30) | PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068297-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |