Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL796239 | 0.90 | HPGD (0.53) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL21998064 | 0.88 | HPGD (0.48) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL2149045 | 0.88 | GPR119 (0.51) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL4227407 | 0.87 | GPR119 (0.48) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL25308738 | 0.85 | KDM4E (0.50) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL13871730 | 0.85 | HPGD (0.48) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL795969 | 0.84 | HPGD (0.53) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL21997138 | 0.84 | HPGD (0.47) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL22126882 | 0.84 | HPGD (0.47) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL795771 | 0.84 | HPGD (0.47) | HPGDKDM4EPKMGPR119RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071313-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018068297-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |