Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.38 |
| ▸ | TPH1 | P17752 | 3/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20072201 | 0.88 | GPR119 (0.37) | GPR119P2RX7 | |
| SCHEMBL21644279 | 0.88 | GPR119 (0.37) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL21644270 | 0.88 | GPR119 (0.37) | GPR119P2RX7 | |
| SCHEMBL20072202 | 0.88 | GPR119 (0.37) | GPR119P2RX7 | |
| SCHEMBL20072010 | 0.88 | GPR119 (0.37) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL20072011 | 0.88 | GPR119 (0.37) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL21644308 | 0.87 | GPR119 (0.36) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL20072283 | 0.87 | GPR119 (0.36) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL20071908 | 0.87 | GPR119 (0.36) | GPR119ACACBACACAMEN1KMT2A | |
| SCHEMBL21644252 | 0.86 | GPR119 (0.35) | GPR119ACACBACACAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068297-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |