Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TPH1 | P17752 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20071834 | 0.95 | NR1H2 (0.39) | FFAR1NR1H2NR1H3GPR119FAAH | |
| SCHEMBL21644283 | 0.90 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4TDP1 | |
| SCHEMBL21644325 | 0.90 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4TDP1 | |
| SCHEMBL20072049 | 0.90 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4TDP1 | |
| SCHEMBL20074082 | 0.89 | FFAR1 (0.34) | FFAR1FFAR4 | |
| SCHEMBL23838199 | 0.88 | NR1H2 (0.36) | NR1H2NR1H3TRPV4 | |
| SCHEMBL21644326 | 0.88 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4L3MBTL1 | |
| SCHEMBL20074046 | 0.88 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4L3MBTL1 | |
| SCHEMBL20071837 | 0.88 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FFAR4L3MBTL1 | |
| SCHEMBL21644153 | 0.88 | NR1H2 (0.39) | FFAR1NR1H2NR1H3FAAHFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526203-B1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2021-09-22 | — | — | EP | disclosed |
| WO-2018071313-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |