Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644220 | 0.95 | FFAR1 (0.34) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20072117 | 0.95 | FFAR1 (0.34) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20074049 | 0.89 | FFAR1 (0.36) | FFAR1FFAR4 | |
| SCHEMBL21644153 | 0.88 | NR1H2 (0.39) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL21644306 | 0.88 | NR1H2 (0.39) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20072012 | 0.88 | NR1H2 (0.39) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL21644332 | 0.86 | TAF1 (0.35) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20071869 | 0.86 | PIK3CA (0.35) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20072116 | 0.86 | TAF1 (0.35) | FFAR1ACHECCR1NPC1RAB9A | |
| SCHEMBL20074059 | 0.86 | PIK3CA (0.35) | FFAR1ACHECCR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526203-B1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2021-09-22 | — | — | EP | disclosed |
| WO-2018071313-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |