Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074310 | 0.99 | KDM5B (0.49) | KDM5BKIF11ALKTSHRCNR1 | |
| SCHEMBL20074325 | 0.91 | KDM5B (0.52) | KDM5BKIF11ALKPDE3BPDE3A | |
| SCHEMBL21681721 | 0.90 | KDM5B (0.51) | KDM5BKIF11PDE3BPDE3ATLR9 | |
| SCHEMBL21721725 | 0.90 | KDM5B (0.51) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL20074307 | 0.89 | KDM5B (0.52) | KDM5BALKTLR9TLR8TLR7 | |
| SCHEMBL21720956 | 0.88 | KDM5B (0.53) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL20074308 | 0.87 | KDM5B (0.40) | KDM5BTSHRTLR9TLR8TLR7 | |
| SCHEMBL31676991 | 0.87 | KDM5B (0.53) | KDM5BKIF11TSHRCNR1TLR9 | |
| SCHEMBL20074250 | 0.87 | KDM5B (0.53) | KDM5BKIF11TSHRCNR1TLR9 | |
| SCHEMBL20074120 | 0.86 | KDM5B (0.52) | KDM5BCNR1TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3525785-B1 | KDM5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-08-27 | — | — | EP | claimed |
| EP-3525785-B1 | KDM5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-08-27 | — | — | EP | disclosed |
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | KDM5B 2/4885KIF11 414/4885ALK 373/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | KDM5B 2/4885KIF11 414/4885ALK 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.