Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074310 | 0.88 | KDM5B (0.49) | KDM5BTSHRTLR9TLR8TLR7 | |
| SCHEMBL20074255 | 0.87 | KDM5B (0.50) | KDM5BTSHRTLR9TLR8TLR7 | |
| SCHEMBL20074325 | 0.87 | KDM5B (0.52) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL21681721 | 0.86 | KDM5B (0.51) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL21721725 | 0.86 | KDM5B (0.51) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL20074307 | 0.85 | KDM5B (0.52) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL21720956 | 0.84 | KDM5B (0.53) | KDM5BTLR9TLR8TLR7 | |
| SCHEMBL20074312 | 0.79 | KDM5B (0.49) | KDM5BTSHR | |
| SCHEMBL20074303 | 0.78 | CCNB2 (0.47) | KDM5BTSHR | |
| SCHEMBL20074328 | 0.78 | KDM5B (0.44) | KDM5BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |