Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23588630 | 1.00 | POLB (0.40) | POLBALDH1A1PIK3CDCYP2D6HRH1 | |
| SCHEMBL20906896 | 1.00 | POLB (0.40) | POLBALDH1A1PIK3CDCYP2D6HRH1 | |
| SCHEMBL21038822 | 0.90 | POLB (0.44) | POLBALDH1A1PIK3CDCYP2D6HRH1 | |
| SCHEMBL24359072 | 0.86 | PIK3CD (0.38) | POLBALDH1A1PIK3CD | |
| SCHEMBL20046564 | 0.86 | SLC6A4 (0.35) | POLBHRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL16997004 | 0.81 | TSHR (0.43) | PIK3CDCYP2D6KCNH2HRH3PTPN7 | |
| SCHEMBL12885052 | 0.81 | HRH3 (0.37) | KCNH2HRH3SLC6A4TSHRPGR | |
| SCHEMBL25461023 | 0.80 | HRH3 (0.36) | KCNH2HRH3TSHRPGR | |
| SCHEMBL25461035 | 0.80 | HRH3 (0.36) | KCNH2HRH3TSHRPGR | |
| SCHEMBL18501245 | 0.79 | HRH3 (0.41) | KCNH2HRH3TSHRPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |