Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | HAVCR2 | Q8TDQ0 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075849 | 0.81 | ALDH1A1 (0.51) | ADORA2AADORA1NPY5RHSD17B10ALDH1A1 | |
| SCHEMBL20076008 | 0.76 | KDM4E (0.46) | NPY5RHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL20076034 | 0.73 | MEN1 (0.48) | LDHAADORA3KDM5BHAVCR2CDC7 | |
| SCHEMBL2197780 | 0.72 | KDM5B (0.43) | ADORA2AADORA1LDHAADORA3KDM5B | |
| SCHEMBL20588719 | 0.72 | KDM4E (0.44) | HSD17B10ALDH1A1HPGDHAVCR2 | |
| SCHEMBL15660543 | 0.71 | KDM4E (0.46) | ADORA1NPY5RHSD17B10ALDH1A1HPGD | |
| SCHEMBL20076013 | 0.71 | PIK3C3 (0.37) | ADORA1HSD17B10ALDH1A1HPGDADORA3 | |
| SCHEMBL20075883 | 0.69 | ADORA1 (0.46) | ADORA1HSD17B10ALDH1A1HPGDKDM5B | |
| SCHEMBL11352 | 0.69 | ADORA2A (0.40) | ADORA2AADORA1NPY5RALDH1A1HPGD | |
| SCHEMBL20075840 | 0.69 | KDM4E (0.41) | HSD17B10ALDH1A1HPGDHAVCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | ADORA2A 3979/4885ADORA1 3457/4885NPY5R 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.