Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 5/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076027 | 0.85 | KDM5B (0.36) | HAVCR2KDM5BKDM5A | |
| SCHEMBL20076023 | 0.83 | KDM5B (0.34) | KDM5BKDM5A | |
| SCHEMBL21681599 | 0.83 | KDM5B (0.34) | HAVCR2KDM5BKDM5A | |
| SCHEMBL20076011 | 0.83 | KDM5B (0.34) | KDM5BKDM5A | |
| SCHEMBL20076175 | 0.79 | KDM5B (0.33) | KDM5BKDM5A | |
| SCHEMBL20076026 | 0.78 | TDP2 (0.36) | KDM5B | |
| SCHEMBL20076020 | 0.77 | TDP2 (0.36) | KDM5B | |
| SCHEMBL20076005 | 0.75 | KDM4E (0.32) | — | |
| SCHEMBL20076018 | 0.74 | KDM5B (0.44) | KDM5B | |
| SCHEMBL20076174 | 0.74 | KDM5B (0.39) | KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | HAVCR2 4388/4885KDM5B 2/4885KDM5A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.