SCHEMBL20077005

SCHEMBL20077005

C=C(Nc1ccccc1N)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.50
HDAC1 Q13547 14/20 0.46
HDAC3 O15379 13/20 0.46
HDAC2 Q92769 12/20 0.46
MAPK1 P28482 1/20 0.46
HDAC10 Q969S8 6/20 0.43
HDAC6 Q9UBN7 6/20 0.43
NCOR2 Q9Y618 5/20 0.43
HDAC4 P56524 5/20 0.43
HDAC7 Q8WUI4 5/20 0.43
HDAC11 Q96DB2 5/20 0.43
HDAC8 Q9BY41 5/20 0.43
HDAC9 Q9UKV0 5/20 0.43
HDAC5 Q9UQL6 5/20 0.43
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 2/20 0.40
GAA P10253 2/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3846828 0.77 PTGS1 (0.58) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL14473364 0.77 RAB9A (0.52) RAB9ANPC1ALDH1A1GAAMAPT
SCHEMBL13850135 0.75 HDAC3 (0.52) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL19486097 0.74 HDAC3 (0.50) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL20040512 0.74 HDAC1 (0.50) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL11946846 0.74 HDAC1 (0.50) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL23465367 0.73 KCNQ3 (0.35) HDAC1NPC1ALDH1A1KMT2A
SCHEMBL20077025 0.73 TMPRSS4 (0.35) GAAMEN1KMT2A
SCHEMBL12965010 0.72 HDAC3 (0.50) PTGS1HDAC1HDAC3HDAC2MAPK1
SCHEMBL15938389 0.72 HDAC1 (0.53) PTGS1HDAC1HDAC3HDAC2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018071327-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-04-19 WO disclosed