Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18844599 | 0.81 | CHRM5 (0.42) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL26345081 | 0.81 | PIK3CD (0.41) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL21506203 | 0.78 | KDM4E (0.37) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL24765448 | 0.76 | PIK3CD (0.42) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL18427493 | 0.74 | PIK3CD (0.41) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL27283973 | 0.74 | PIK3CD (0.41) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL12436 | 0.74 | PIK3CD (0.41) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL23386418 | 0.74 | CHRM5 (0.36) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL772434 | 0.73 | PIK3CD (0.40) | CHRM5ADRA2CKDM4EPIK3CDPOLB | |
| SCHEMBL24997025 | 0.73 | CYP2D6 (0.44) | CHRM5ADRA2CKDM4EPIK3CDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951062-B2 | Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-04-24 | — | — | US | disclosed |