Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478430 | 0.85 | — | — | |
| SCHEMBL12478238 | 0.83 | PRMT1 (0.46) | PRMT1PRMT3CARM1PRMT6PRMT8 | |
| SCHEMBL8334637 | 0.81 | PRMT1 (0.44) | PRMT1PRMT3CARM1PRMT6PRMT8 | |
| SCHEMBL21386236 | 0.81 | PIK3CD (0.47) | PIK3CDNPC1RAB9AALDH1A1 | |
| SCHEMBL18233621 | 0.79 | PIK3CD (0.55) | PIK3CDNPC1RAB9A | |
| SCHEMBL19402495 | 0.79 | PRMT3 (0.42) | PRMT1PRMT3CARM1PRMT6PRMT8 | |
| SCHEMBL2002550 | 0.79 | PRMT1 (0.42) | PRMT1PRMT3CARM1PRMT6PRMT8 | |
| SCHEMBL24951687 | 0.78 | PIK3CD (0.44) | PIK3CDNPC1RAB9A | |
| SCHEMBL13744550 | 0.78 | CARM1 (0.41) | PRMT1PRMT3CARM1PRMT6PRMT8 | |
| SCHEMBL13136119 | 0.77 | PIK3CD (0.43) | PIK3CDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021154669-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-05 | — | — | WO | disclosed |
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-9951065-B2 | Benzimidazole and imadazopyridine carboximidamide compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |