Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 15/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 15/20 | 0.55 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20079262 | 0.90 | CARM1 (0.59) | CARM1PRMT6PRMT8PRMT1TMEM97 | |
| SCHEMBL14508589 | 0.90 | CARM1 (0.59) | CARM1PRMT6PRMT8PRMT1TMEM97 | |
| SCHEMBL21386063 | 0.90 | CARM1 (0.59) | CARM1PRMT6PRMT8PRMT1TMEM97 | |
| SCHEMBL18256915 | 0.89 | CARM1 (0.42) | CARM1PRMT6PRMT8PRMT1BCHE | |
| SCHEMBL18233590 | 0.82 | CARM1 (0.35) | CARM1PRMT6PRMT8PRMT1BCHE | |
| SCHEMBL21386115 | 0.80 | — | — | |
| SCHEMBL17888266 | 0.79 | CARM1 (0.60) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL17888267 | 0.79 | CARM1 (0.60) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL17277592 | 0.79 | CARM1 (0.60) | CARM1PRMT6PRMT8PRMT1HRH3 | |
| SCHEMBL14792301 | 0.79 | DRD2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-9951065-B2 | Benzimidazole and imadazopyridine carboximidamide compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |